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Introducing the New GPU-Rich Software-Defined Infrastructure Systems

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29 Aug 2025
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Introduction

Introducing the new GPU-rich software-defined infrastructure systems, the new ThinkAgile HX650a V4, MX650a V4, and VX650a V4.

Unleash next-level performance with support for up to 4 double-wide GPUs with NVLink support and purpose-built for compute-intensive AI workloads, virtual desktops, and graphics intensive applications.

ThinkAgile HX650a V4

Lenovo ThinkAgile HX Series, pre-integrated with Nutanix software, delivers a seamless hybrid multi-cloud solution, providing simplicity and freedom to harness the power of AI with flexibility, scalability, and security across workloads from edge to cloud.

ThinkAgile HX650a V4 models are designed for deploying industry-leading hyperconvergence software from Nutanix on Lenovo enterprise platforms. Nutanix brings the benefits of web-scale technologies to enterprise applications through enterprise storage, data protection, infrastructure resilience, management and analytics, and security.

HX650a V4
Figure 1. ThinkAgile HX650a V4

The ThinkAgile HX650a V4 system offers the following key features:

  • Factory-integrated, pre-configured ready-to-go integrated systems built on proven and reliable Lenovo ThinkSystem servers that provide compute power for a variety of workloads and applications and powered by industry’s most feature-rich hyperconverged infrastructure software from Nutanix.
  • Provide quick and convenient path to implement a hyperconverged solution powered by Nutanix with "one stop shop" and a single point of contact provided by Lenovo for purchasing, deploying, and supporting the solution.
  • Meet various workload demands with performance-optimized all NVMe storage configurations
  • Deliver fully validated and integrated hardware and firmware that is certified with Nutanix software.

For more information, see the ThinkAgile HX650a V4 product guide.

ThinkAgile MX650a V4

Lenovo ThinkAgile MX Series allow customers to easily accelerate and modernize their AI and hybrid cloud infrastructure by enabling Azure cloud services at the edge and in their own data center.

The ThinkAgile MX650a V4 is designed for deploying highly available, highly scalable hyper-converged infrastructure (HCI) and software-defined storage (SDS) from Microsoft on Lenovo enterprise platforms. The ThinkAgile MX650a V4 solution offers varying levels of included software, support, and pre-validation.

MX650a V4
Figure 2. ThinkAgile MX650a V4

The ThinkAgile MX650a V4 offers the following key features:

  • Continuously tested and validated by Lenovo and Microsoft with single point of support for HW and L1, L2 SW support from Lenovo to ensure higher reliability and less downtime.
  • Quick and convenient path to implement a hyperconverged solution powered by the Azure Local OS with Hyper-V virtualization, Microsoft Storage Spaces Direct (S2D) Software Defined Storage (SDS), and Software Defined Networking (SDN) network virtualization.
  • Streamlined management of Azure Arc enabled servers with unified single-pane-of-glass for creating and managing VMs, S2D volumes, and virtual networks with Azure Portal or Windows Admin Center with Lenovo xClarity Integrator.
  • Solution Builder Extension (SBE) integration with Azure Arc.

For more information, see the ThinkAgile HX650a V4 Product Guide.

ThinkAgile VX650a V4

With faster deployments and seamless operational management, ThinkAgile VX Series co-engineered HCI solution and ThinkAgile Converged Solution for VMware enable optimized investments for private and hybrid cloud-based VMware environments.

The Lenovo ThinkAgile VX650a V4 offer the ultimate in two-socket GPU-rich performance in a 2U form factor. Based on VMware software, the system offers a unique, software-defined approach to hyper convergence, leveraging the hypervisor to deliver compute, storage and management in a tightly integrated software stack.

VX650a V4
Figure 3. ThinkAgile VX650a V4

The ThinkAgile VX650a V4 offers the following key features:

  • Factory-integrated, pre-validated ready-to-go integrated systems built on proven and reliable Lenovo ThinkSystem servers that provide compute power for a variety of workloads and applications and powered by industry-leading hyperconverged infrastructure software from VMware.
  • Fully tested and validated for vSAN compliance with VMware and includes the latest supported firmware levels integrated at factory.
  • Provide quick and convenient path to implement a implement a private or hybrid cloud environment powered by VMware Cloud Foundation (VCF) or VMware vSphere Foundation (VVF) software stacks. Purchasing the software licenses through Lenovo provides a "one stop shop" and a single point of contact from Lenovo for purchasing, deploying, and supporting the solution.

For more information, see the ThinkAgile VX650a V4 Product Guide.

Based on the ThinkSystem SR650a V4

The HX650a V4, MX650a V4 and VX650a V4 are all based on the ThinkSystem SR650a V4 platform.

The SR650a V4 is an ideal 2-socket 2U rack server for customers want to maximize GPU compute power while still retaining the traditional 2U rack form factor. With two Intel Xeon 6700-series or 6500-series processors, plus support for four double-wide GPUs including the NVIDIA H100 NVL 94GB, the SR650a V4 is designed for high density and scale-out workloads.

The ThinkSystem SR650a V4 offers numerous features to boost performance, improve scalability and reduce costs:

  • Supports one or two Intel Xeon 6700-series or 6500-series processors with Performance-cores (P-cores), up to 350W
  • Support for DDR5 memory DIMMs to maximize the performance of the memory subsystem, up to 8TB of memory
  • Supports up to 4x double-wide GPUs with dual-GPU NVLink support, or 8x single-wide GPUs, installed at the front of the server, for substantial processing power in a 2U system.
  • Supports up to 8x 2.5-inch NVMe hot-swap drive bays or 8x E3.S 1T NVMe hot-swap drives for local storage.
  • Up to 8x PCIe slots (front accessible) for GPUs and 6x PCIe slots (rear accessible) for other PCIe adapters, plus two slots dedicated to OCP 3.0 adapters.

For more information on the SR650a V4, see these resources:

For more information

For more information, see the ThinkAgile Software-Defined Infrastructure product web page.

Related product families

Product families related to this document are the following:

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The following terms are trademarks of Lenovo in the United States, other countries, or both:
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